endobj ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Comprecel|MINGTAI CHEMICAL Performing this action will revert the following features to their default settings: Hooray! Packaging: 34 x 50 kgs fiber drums. Material safety data sheet - FMC Corporation - YUMPU They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Avicel PC 611 (FMC Biopolymer) | CosmeticsAndToiletries.com Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Substance Information - ECHA - Europa Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Battista, O. };khd5x=fr PDF (4.11 mb) Footer menu 1. Learn about FMC's industry leading goal of net-zero emissions by 2035. CAS #: 9004-34-6 . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Micro Crystalline Cellulose. undefined. Quantity: 1 700 kgs. Biologicals by FMC. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. PDF MATERIAL SAFETY DATA SHEET - Pfizer Manufactured by: China . The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Safety Data Sheet (SDS) Viewer. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Have an order or account question? JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . SUBSTANCE IDENTIFICATION 1.1. 1.3. However, it yields non-digestible fibre. %PDF-1.4 II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. However, if handling bulk powders, observance of appropriate safeguards is recommended. (Microcrystalline Cellulose Market Pr. % Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. P}MFbN#[>r(y Page 1 of 8. MATERIAL SAFETY DATA SHEET - Sevron At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. (&E. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) MSDS Ref. Microcrystalline Cellulose (MCC): Benefits, Side Effects & Dosage In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. 9,LL!z q9;v80q>jZ These, in turn, are assembled into fibrils in the cell wall. Microcrystalline Cellulose Side Effects. Synonyms: Cellulose, Cellulose powder, Cotton linters. PDF PRODUCT OVERVIEW: Avicel PH-200 - Signet INCI. Production of Pharmaceutical Grade Microcrystalline Cellulose. Document(s): certificate data msds. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. All rights reserved. Your file is uploaded and ready to be published. The typical mean particle size is 20200 m. The figure below illustrates the structural organisation of cellulose within plants. Report Category. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Avicel RC 591 MSDS CasNo.51395-75-6 - lookchem.com Learn about FMC's differentiated biologically-based crop solutions. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. <> X\o^ POLYOX resins are nonionic polyethylene oxide solubility polymers. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. . Revision No. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Avicel Microcrystalline Cellulose Physical Properties. Product Name Cellulose microcrystalline. % Avicel PC 611 (FMC Biopolymer) Supplied by. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P MATERIAL SAFETY DATA SHEET - Sevron It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. %PDF-1.4 Some substance identifiers may have been claimed confidential, or may . It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Alginates also function as actives in some anti-reflux products. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. (1962). on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. AVICEL RC 581 at Rs 140/kg | Pharmaceutical Excipients in - IndiaMART <> The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. : 51395-75-6 Date Approved: 01/31/2008 Revision No. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. 2008-2023 ChemPoint. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? CAS No. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. CAS 9004-34-6, pH 5 - 7.5. We can send by Fedex, by ship or by plane according to international rules. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. The aqueous solution to barrier membrane coating. Molecular Weight null. Find answers in our support articles. EMCOCEL XLM 90. endobj It . )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC stream Watch Now. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. ( gwf;J(e0o|1p{R~P^);ao!%{0KD7. endobj CAS 9004-34-6. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Protect them from sunshine or rain. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. Doses up to 30 g per day appear to be . FMC Corporation. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. (PDF) Commercial sources of "Avicel RC/CL" and its - ResearchGate Heavy metals, % NMT 0.001 % endobj More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. Combines good flow and high compactibility. 4 0 obj q86@on$^X_HuH;3` Microcrystalline cellulose (cas 9004-34-6) SDS(Safety Data Sheet) /MSDS ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. EINECS #: 232-674-9 1.7. 4 0 obj stream Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Microcrystalline Cellulose / Avicel PH-102 - Chemical - Stobec Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. JFIF ` ` ZExif MM * J Q Q Q C Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. It is also inert and biocompatible. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, % Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . PDF Material Safety Data Sheet (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC l~5C Thus, Avicel contributes no or very few calories to the food system. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. A., and Smith, P. A. endobj pH 6.0 to 8.0 . Cellulose, microcrystalline | C14H26O11 - PubChem Terms and Conditions Compliance Solutions Industries About 3E News & Events . The cellulose molecule is formed through repeated condensation of cellobiose units. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. . 1.3. stream MATERIAL SAFETY DATA SHEET. 130. PDF (28.38 mb) 2022 Corporate Fact Sheet. PDF Pharma Solutions Avicel Co-Processed Product Selection Guide - DuPont Microcrystalline cellulose is a commonly used excipient in the . Manufacturer: FMC BioPolymer. Van Veen, G.K. Bolhuis, Y.S. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Cellulose microcrystalline MSDS - 102331 - Merck [FMC Study Number I92-1464]. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. High performance lubricant that brings more to the tablet. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. ). FMC, JRS and Mingtai were estimated to hold for . In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. There may be more fiber in your food than you realized. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. It is also used in plaque assays for counting. Avicel RC-591 & CL-611 - Description. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . . A family of polysaccharide products that allow distinctive drug delivery solutions. . Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Microcrystalline Cellulose. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world.

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