Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Avoid using comfrey together with other herbal/health supplements that can also harm the liver. View abstract. In a multicenter, randomized, double-blind, placebo-controlled study with 142 ankle sprain participants, a comfrey root extract applied 4x/day for 8 days improved pain, swelling, and mobility without any adverse reactions (Koll et al., 2004). The following applications have been used in research: Using large amounts of comfrey cream or using it for extended periods of time increases the risk of side effects like liver toxicity. Comfrey oil is made by infusing the leaves and roots of a comfrey plant with a neutral oil. View abstract. Its long, lance-shaped leaves can be up to 1 foot in length closer to the bottom of the stem and are shorter higher up the stem. Links to external sites are for informational purposes only. Yield: Approximately 5 cups of whipped lotion. View abstract. (10), 707-714. https://doi.org/10.1016/j.phymed.2005.06.001. Using a supplement like comfrey may have potential side effects. Comfrey cream , meaning to grow together. Call your doctor for medical advice about . View abstract. We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. An ankle sprain can come out of nowhere and cause a lot of pain, limitations, and regret until it is healed. This recipe is contraindicated for small children and those with certain medical conditions. Using it no more than four to six weeks a year as a general guideline would be best. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. The chemicals contained in comfrey may cause birth defects. Comfrey might harm the liver. It is not certain whether comfrey is effective in treating any medical condition. Allow the oil mixture to cool until it reaches room temperature, which could take 8-12 hours. Arzneimittelforschung, 62(06), 285-289. https://doi.org/10.1007/s10354-007-0474-y, Giannetti, B. M., Staiger, C., Bulitta, M., & Predel, H. G. (2010). It should only be used in small amounts for short periods as a cream. Whether youre familiar with it or not, this unusual herbal remedy is definitely worth knowing more about. Make sure to always buy comfrey. The leaves and stems of comfrey contain pyrrolizidine alkaloids that can cause toxic damage if ingested in excess (Ulbricht, 2010). Comfrey cream combines ingredients like oils or water and glyceryl stearate with Symphytum officinale (comfrey) extracts. Stewart MJ, Steenkamp V. Pyrrolizidine poisoning: a neglected area in human toxicology. Comfrey Oil: Benefits, Uses & Risks | Holland & Barrett In a randomized, double-blind, placebo-controlled trial, 220 patients with knee osteoarthritis used either a commercial topical comfrey root extract or a placebo. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. Be sure to choose organic carrier oils and essential oils when possible. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. https://doi.org/10.1007/s10354-007-0474-y. 2005 - 2023 WebMD LLC. 2012;20(11):1209-16. doi:10.1016/j.joca.2012.07.019, Zago LR, Prado K, Benedito VL, Pereira MM. WebMD does not provide medical advice, diagnosis or treatment. Comfrey cream may help treat knee osteoarthritis, according to a Cochrane review of topical herbal therapies. View abstract. 2010;13(7-8):509-526. doi:10.1080/10937404.2010.509013, Staiger C. Comfrey: A clinical overview. 2007;14(1):2-10. Centurian, South Africa: Medpharm Scientific Publishers. View abstract. The participants were assigned three weeks of treatment with two grams of either comfrey ointment or a placebo three times a day. Here's a look at research on comfrey cream for back pain, osteoarthritis, and ankle sprains. Stam, C., Bonnet, M. S., & van Haselen, R. A. Comfrey contains chemicals called. Huxtable RJ, Awang DV. comfrey cream holland and barrett - creditsolutionexperts.com Megan Nunn, PharmD, is a community pharmacist in Tennessee with twelve years of experience in medication counseling and immunization. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. D'Anchise, R., Bulitta, M., and Giannetti, B. Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). Comfrey. Symphytum officinale), store bought or via recipe, above. cup organic safflower oil It is easily absorbed to leave your skin feeling fresh, soft and radiant. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Herbal drugs and phytopharmaceuticals. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Supplements marketed for body-building (ex.. Contact your doctor or pharmacist if you have any questions before use. Store at room temperature away from moisture and heat. NIH Office of Dietary Supplements. The herbal topical cream was prepared at two different strengths, as an additional measure of efficacy. However, further well-designed studies are needed. Registered in England: company no. Satisfaction. #HBTechCareers. Staiger, C. Comfrey: a clinical overview. New South Wales Health, Australia. J Toxicol Environ Health B Crit Rev. There is no daily recommended allowance for comfrey, sold in creams, ointments, gels, and salves. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: Results of a double-blind, randomised, bicenter, placebo-controlled trial. Choose a supplement tested by a trusted third party, such as USP, ConsumerLabs, or NSF when possible. Barna, M., Kucera, A., Hladikova, M., & Kucera, M. (2012). A multi-center, randomized, double-blind, controlled clinical trial was conducted with 161 patients having acute lower back pain. This is the tincture. cup organic sunflower oil Registered VAT no. Like any new treatment, discontinue use if any irritation occurs. Can a comfrey (Symphytum officianale) root extraction help ease aching joints and muscles? This comfrey cream recipe works great for local areas that have mild bruising or soft tissue pain. Some medications can also harm the liver. Topically, comfrey root and leaf extracts have been traditionally used for bruises, sore muscles and joints, sprains, mild wounds, and gout (Natural Medicines, 2020). Kucera, A., Barna, M., Holcova, S., Horacek, O., Hladikov, M., & Ottillinger, B. 1.35 Fl Oz. Be sure to choose organic carrier oils and essential oils when possible. doi:10.1002/14651858.CD010538, Smith DB, Jacobson BH. Efficacy of a comfrey root (Symphyti offic. This is done by soaking the root in at least 50% alcohol for a minimum of two weeks. Additionally, there is scientific research demonstrating comfreys effectiveness at soothing muscle and joint pain, some of which are highlighted in this post. Using a combination product makes it challenging to know how much of the beneficial effect came from comfrey alone. This is not a complete list of side effects and others may occur. Discontinue use if a rash develops. These side effects may be common or severe. Safety Alerts & Advisories: FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. Of course, more research is needed to validate efficacy and safety. It contains chemicals that are poisonous. Efficacy of a comfrey root (Symphyti offic. To make this recipe, first, you must prepare the comfrey root tincture. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. A symptomatic treatment of minor sprains and bruises. Acupuncture has also shown solid evidence of benefit for back pain. randomized, placebo-controlled, double-blind, multi-clinical trial. (3), 147-156. https://doi.org/10.1016/j.jcm.2011.01.003. In a double-blind, randomized, placebo-controlled study involving 120 patients with acute back pain, symptoms were quickly reduced in the group using 4 grams of an ointment containing 35% comfrey root extract 3x/day for 5 days (Giannetti et al., 2010). As an additional measure of efficacy, groups instructed to use the comfrey preparation for the longest period of time experienced the most improvement. Avoid comfrey with certain medical conditions, such as liver disease. Select a condition to view a list of vitamins. 2 cups organic, unrefined coconut oil Wien Med Wochenschr. View abstract. 2018;19(5):455-474. doi:10.1016/j.jpain.2017.11.005, Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Pour into bowl /jug big enough for all ingredients and safe for the mixer. 2013;27(6):811-7. With extract of Comfrey. Comfrey is not recommended for children under three years old, as it's not been studied in that population. Swiss.Med.Wkly. The recipe makes about 6 small jars. Do not use this product if you have a sensitivity to any of the ingredients. 12 drops peppermint (Mentha piperita) essential oil . 2013;163:5864 (2013) doi:10.1007/s10354-012-0162-4, Giannetti BM, Staiger C, Bulitta M, Predel HG. Regarding its antioxidant, antilipoperoxidant, antiinflammatory, and cytotoxic properties. Wound-healing effects of a symphytum herb extract cream (. Book your free, one-to-one online consultation with one of our qualified advisors. 2020;142:104519. Comfrey may have been applied to the skin in a specific preparation to treat some of these conditions. Kucera, M., Barna, M., Horacek, O., Kalal, J., Kucera, A., and Hladikova, M. Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study. Hybrids and other species may have a similar appearance but could have significantly different amounts of the toxic pyrrolizidine alkaloids (Kucera et al., 2018). View abstract. Some drugs increase how quickly the liver changes and breaks down comfrey. The warm weather has a way of encouraging us to get outside and move our bodies more. comfrey cream holland and barrett. Comfrey may also be used for purposes not listed in this product guide. Glass bowl with a lid Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Journal of chiropractic medicine, 10(3), 147-156. https://doi.org/10.1016/j.jcm.2011.01.003, Stam, C., Bonnet, M. S., & van Haselen, R. A. For this reason, some topical products are advertised as made from comfrey leaves, but it's safest to choose a PA-free product. Medically reviewed by Drugs.com on Feb 8, 2023. Drugs and Lactation Database (LactMed). Read our. Comfrey root extracts have been used by herbalists and in folk traditions for centuries to soothe aches and pains. Knit bone, Eucalyptus, Rapeseed Oil, BHA. Natural Standard. 2013;163(3-4):58-64. This is not recommended due to the presence of chemicals that can cause organ damage and cancer. The ointment has a very mild herbal fragrance and is soothing on application. Staiger C. Comfrey root: from tradition to modern clinical trials. 2013;21(6):724-745. doi:10.1016/j.ctim.2013.09.009. Staiger, C. Comfrey root: from tradition to modern clinical trials. Heat oil in double boiler gently then add beeswax until it melts. (21), 498-507. https://link.springer.com/article/10.1007/s10354-004-0114-8, Natural Medicines (2020). Follow all directions on the product label and package. Cap, then label the jars with the date made and ingredients. How to Make and Use Comfrey Fertilizer - The Spruce Please read the Topical Use Safety section of this article (above) before using. Avoid with medications that induce CYP3A4 or are hepatotoxic (Natural Medicines, 2020). It produces clusters of purple, blue, and white flowers, and it's famous for its long . Regulatory Toxicology and Pharmacology, 83, 1-4. https://doi.org/10.1016/j.yrtph.2016.11.015. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: Comfrey is considered likely unsafe to use during pregnancy. Comfrey root: from tradition to modern clinical trials, Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial, Topical herbal therapies for treating osteoarthritis, Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials, Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. comfrey cream holland and barrett - daxasys.com This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. After the tincture is made, then you can whip up the fabulous joint and muscle cream! Drug-induced liver injury. June 3, 2022 Posted by: Category: Uncategorized; No Comments . 1 It's found in Europe, Asia, and North America. 98% Naturally derived. Giannetti, B. M., Staiger, C., Bulitta, M., & Predel, H. G. (2010). Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Transfer the cooled oil and butter mixture to a standing electric mixer or blender. The Food and Drug Administration (FDA) released an advisory in July 2001 recommending that comfrey products be removed from the market because of cases of hepatic veno-occlusive disease. A review of 26 clinical trials concluded that mild skin reactions were the most common side effects of comfrey creams used in the studies. Comfrey is a fast-growing plant whose leaves and roots have been used historically for wound healing and other conditions. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. This perennial can grow up to 4-feet tall. Comfrey [Online article]. Yield: Approximately 5 cups of whipped lotion. View abstract. In a small study with 30 subjects, lower back pain from exercise was reduced with an ointment containing comfrey. 2012;26(10):14411448. What are the benefits of using it? Phytomedicine, 14(1), 2-10. https://doi.org/10.1016/j.phymed.2006.11.006, Jedlinszki, N., Balzs, B., Csnyi, E., & Csupor, D. (2017). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Phytother.Res 2012;26(10):1441-1448. Ther Drug Monit 2001;23:698-708. Laslett, L. L., Quinn, S. J., Darian-Smith, E., Kwok, M., Fedorova, T., Korner, H., Steels, E., March, L., and Jones, G. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. Other drugs may interact with comfrey, including prescription and over-the-counter medicines, vitamins, and herbal products. Symphytum officinale L., dermal use (Flexagile cream)]. Mix for about 10 minutes, until nice and whipped. Written by Cerner Multum. OTHER NAME(S): Ass Ear, Black Root, Blackwort, Bruisewort, Common. A significant reduction in pain was observed in the groups using the comfrey product. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. Ingesting cooking oil has been banned by the European Union, due to a high risk of liver toxicity.9, Adults with liver disease, cancer, or a history of alcoholism are also advised to avoid comfrey because the skin can also absorb the liver-damaging compounds. Smith, D. B., & Jacobson, B. H. (2011). Comfrey has long been used in folk traditions for bruising and abrasions. Find out how to use it here along with its benefits. Rad. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. Although topical comfrey has been used for this indication, there's little evidence that it helps and can pose a big risk for nursing babies. 2013;21(6):724-45. British Homeopathic Journal, 90(01), 21-28. https://doi.org/10.1054/homp.1999.0460. Herbal medicine for low back pain: A Cochrane review, Dietary Supplements: What You Need to Know, Sinusoidal obstruction syndrome (blockage of veins in the liver). Here's 10 things essential oils are great for. Ulbricht, C. (2010). It's typically only used in small amounts for a very short period. While there can be a variety of causes for back pain, these small studies offer hopeful results that comfrey root may offer potential analgesic and anti-inflammatory benefits. reduce lower back pain (Stam et al., 2001). Copyright Holland & Barrett Limited 2023. Liver injury from herbal and dietary supplements. Call your doctor if the condition you are treating with comfrey does not improve, or if it gets worse while using this product. To make the cream, combine sunflower oil, safflower oil, coconut oil, and cocoa butter in a double-boiler over low heat until completely melted. As we are constantly reviewing and developing our products to meet our consumer needs, consumers, particularly those that suffer from allergies and intolerances, should always check product labelling, warnings, and directions provided with the product that is delivered, prior to use or consumption. Close LOGIN FOR DONATION. Safety Alerts & Advisories: FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. Join Rewards for Life today and we'll give you 300 points worth 3, Save 5% on your favourite products, plus get the lowest price from the last 90 days and free delivery on orders over 10. Hepatology. Two interesting studies found that a topical application of a product containing comfrey root extract helped with knee pain and stiffness. Drug class: Herbal products. This is not a complete list of side effects and others may occur. View abstract. Small glass jars with lids for sharing (optional). Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Am J Med 1990;89:547-8. Arzneimittelforschung. Comfrey oil should be applied topically to parts of the body where you have muscular pain or discomfort. Therapeutic use of comfrey is limited because of its toxicity. (2004). Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. byBhupesh Panchal, Senior Regulatory Affairs Associate, Comfrey oil is a herbal oil that moisturises skin, and thats been used as a healing herb for a long time.1, Since at least the 4th century, people have used comfrey medicinally. 1. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Registered VAT no. 95 ($14.78/Fl Oz) FREE delivery Wed, Mar 8 on $25 of items shipped by Amazon. Br J Sports Med. 16 Rewards for Life points with this purchase. Available for Android and iOS devices. Scientific studies have shown comfrey oil can help reduce the likelihood leg ulcers will become infected.7, Topical application of comfrey oil has been shown to support the lower and upper back more than methyl nicotinate, the main ingredient in many muscle creams.8. Comfrey: Uses, Risks, and Takeaways - Healthline Some people ingest comfrey roots or leaves or use them in teas. Comfrey contains chemicals that cause serious liver damage when taken by mouth. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. MedlinePlus Medical Encyclopedia. The use of babosa (Aloe vera) in treating burns: a literature review. However, not a rate considered harmful for those with healthy livers.10,11, Masters Degree in Toxicology and BSc Hons in Medical Biochemistry. Discard after a year or according to labeling. A critical scoping review of external uses of comfrey (Symphytum spp.). 12 drops juniper berry (Juniperus communis) essential oil Medicinal use of this product has not been approved by the FDA. Store comfrey cream according to package instructions, typically at room temperature and out of reach of children and pets. Symphyti) in the treatment of ankle distorsions: Results of a multicenter, randomized, placebo-controlled, double-blind study. Company number 02758955 Registered VAT number 211727395. Homeopathy. Recent studies have suggested topical benefits, but more research is needed. Taking comfrey along with a medication that can harm the liver might increase the risk of liver damage. Discontinue use if a rash appears. Looks like you may need to upgrade your browser We're sorry, we no longer support the web browser that you are using A large review released in 2013 about the medicinal uses of comfrey stated: It is clinically proven to relieve pain, inflammation and swelling of muscles and joints in the case of degenerative arthritis, acute myalgia in the back, sprains, contusions and strains after .

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